As we mentioned in previous articles, infertility is defined as inability of a couple to conceive after 12 months of unprotected sexual intercourse or can not carry the pregnancy to term. It effects over 5 millions couple alone in the U. S. and many times more in the world. Because of unawareness of treatments, only 10% seeks help from professional specialist. In this article, we will discuss what is male infertility Human zona pellucida binding test ??I. DefinitionThe testes help to exam how the sperm bind to outer layer of the egg, including hemizona assay.II. ProcedureThe test is necessary if the men is found to be infertile with either reduced sperm count, motility and morphology alone, or in combination and is classified with unexplained causes. The sperm and egg are collected from a couple and is used to see the sperm penetration in IVF.III. DiagnosisThe process of human fertilization, sperm must bind to the zona pellucida, undergo the acrosome reaction, penetrate the the out layer of the egg and then fuse with the oolemma. The process is observed and recorded. If the sperm can not penetrate the egg then other testes may be needed or conception may be required more technical support. If the sperm has no problem in egg penetrating, then IUI or IVF is the best choice in assisting the fertilization for a unfertilized couple.IV. RiskAlthough the successful rate to conceive is very high, if a couple pass the humanzona pellucida binding test, but it is not 100% guaranteed, since for a couple to get conceive, it takes more than human zona pellucida test.For the best pregnancy self help program review, please visithttp://bestfertility.blogspot.com/For series of Infertility Articles, please visithttp://fertility-infertility.blogspot.com